How do self-assembling polymers and gels age compared to glasses?

Expanding the scope of gels に combining polymers with low-molecular-weight gelators to yield modified self- assembling smart materials with high-tech applications

Temperature-responsive gels and thermogelling polymer matrices for protein and peptide delivery.

The explosive development of protein and peptide drugs has ushered in a great need for effective delivery systems for such drugs. Two decades of studies of protein delivery from polymeric systems has revealed the great potential of gels that respond to environmental stimuli, such as temperature, pH, etc. Protein and peptide release can be engineered to occur in a pulsatile mode. The mechanism o...

Injectable shear-thinning hydrogels engineered with a self-assembling Dock-and-Lock mechanism.

Injected therapeutics, such as cells or biological molecules, may have enhanced efficiency when delivered within a scaffold carrier. Here, we describe a dual-component Dock-and-Lock (DnL) self-assembly mechanism that can be used to construct shear-thinning, self-healing, and injectable hydrogels. One component is derived from the RIIα subunit of cAMP-dependent kinase A and is engineered as a te...

Mechanical Behavior and Microstructure of Self - Assembling Oligopeptide Gels

Hydrogels have become widely used in the fields of tissue engineering and drug delivery. One class of hydrogel is formed from synthetic oligopeptides that self-assemble into a solution of beta-sheet filaments. These filaments can aggregate to form a gel suitable for culture of various cell types. Examples of such self-assembling peptides are RAD16-I, RAD16-II, and KLD-12. One limitation of self...

Experimental and Theoretical Investigation of Gelation Time of Nanostructured Polymer Gels by Central Composite Approach

Currently available polymers as a component of in-situ gels are unsuitable for treating high-temperature/high-salinity reservoirs due to their chemical and thermal degradation. In this study, a new copolymer-based gel system including high molecular weight nanostructured polymers (NSPs) was developed to address the excessive water production problem in reservoirs under harsh conditions. The sta...